abstract: A phase II evaluation of Lapatinib in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: A GOG group study Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Wednesday, February 08, 2012

abstract: A phase II evaluation of Lapatinib in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: A GOG group study



Conclusions

Lapatinib has minimal activity in recurrent ovarian cancer. Ki-67 expression may be associated with prior PFS and a polymorphism in EGFR exon 20 (2361G>A, Q787Q).

Highlights

► Lapatinib has minimal activity in unselected recurrent ovarian cancer.
► Ki-67 expression may be associated with prior PFS and a polymorphism in EGFR exon 20.
► EGFR and HER2/neu are overexpressed in a minority of ovarian cancers.

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