abstract: Retrospective study comparing irinotecan (CPT-11) and pegylated liposomal doxorubicin in treatment of recurrent platinum-refractory/resistant epithelial ovarian cancer (Japan)

Blogger's Note: older studies have also included efficacy in clear cell ovarian tumors

 Abstract

PURPOSE:

The standard regimen for platinum-resistant/refractory recurrent epithelial ovarian cancer (EOC) remains to be determined. In this study, we retrospectively compared the effect of irinotecan (CPT-11) and pegylated liposomal doxorubicin (PLD) in the treatment of platinum-resistant recurrent EOC.

METHODS:

Thirty patients who received salvage chemotherapy with CPT-11 or PLD were included in the study. CPT-11 (100 mg/m2) was administered intravenously on days 1, 8 and 15 every four weeks. PLD (50 mg/m2) was administered on day 1 every four weeks. Treatment was repeated, provided that no disease progression or intolerable toxicity occurred.

RESULTS:

Response rate in the CPT-11 group and PLD group showed no difference at 26.7% in both, while non-PD rate was 73.3% vs. 33.3%, respectively. Progression-free survival after CPT-11 treatment and PLD treatment was 28.4 weeks and 16.8 weeks, respectively. Hand-foot syndrome and mucositis were more common in the PLD group than in the CPT-11 group.

CONCLUSIONS:

The results indicate that CPT-11 is a promising drug for the treatment of platinum-resistant recurrent EOC.