PLoS ONE: Integrated Analyses of microRNAs Demonstrate Their Widespread Influence on Gene Expression in High-Grade Serous Ovarian Carcinoma
Background
The
Cancer Genome Atlas (TCGA) Network recently comprehensively catalogued
the molecular aberrations in 487 high-grade serous ovarian cancers, with
much remaining to be elucidated regarding the microRNAs (miRNAs). Here,
using TCGA ovarian data, we surveyed the miRNAs, in the context of
their predicted gene targets.
Conclusions
This
study establishes miRNAs as having a widespread impact on gene
expression programs in ovarian cancer, further strengthening our
understanding of miRNA biology as it applies to human cancer. As with
gene transcripts, miRNAs exhibit high diversity reflecting the genomic
heterogeneity within a clinically homogeneous disease population.
Putative miRNA:mRNA interactions, as identified using integrative
analysis, can be validated. TCGA data are a valuable resource for the
identification of novel tumor suppressive miRNAs in ovarian as well as
other cancers.
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