open access: Progression-free Survival Decreases with Each Subsequent Therapy in Patients Presenting for Phase I Clinical Trials (study included various cancers including ovarian cancer) note: patient warning before reading

Blogger's Note: patient warning - this is not a 'good news' paper so caution advised

Table I 
Patient Diagnoses, Gender, Median Age at Diagnosis and Median Number of Therapies  (Blogger's Note: total patients = 142; ovarian cancer patients = 11)

Patient Characteristics

"We reviewed the patient records of 165 unique patients that were evaluated for participation in six phase I trials. Due to a lack of specific start/stop dates, 25 patients had at least one treatment censored for analysis; with one of these patients not having PFS that could be calculated for this study. Seventeen of these twenty-five patients were diagnosed as having less than stage IV disease, with the majority of censored treatments (radiation, surgery, or neoadjuvant or adjuvant chemotherapy) occurring in the non-advanced/metastatic setting. One hundred forty-four patients met criteria for receiving at least one prior non-investigational systemic therapy for advanced/metastatic cancer prior to coming for a phase I treatment evaluation. There were 77 men and 65 women; median age at cancer diagnosis was 55.3 years (range, 9.4 - 81.6 years). The most common types were: colorectal cancer (n=20 (13.9%)), other gastrointestinal cancer (n=17 (11.8%)), adenocarcinoma of the prostate (n=17 (11.8%)), non-small cell lung cancer (NSCLC) (n=13 (9.0%)), breast cancer (n=12 (8.3%)), ovarian cancer (n=11 (7.6%)), and adenocarcinoma of the pancreas (n=9 (6.3%)) (Table I). Patients had a median of three chemotherapy or hormonal treatments (mean, 3.32 treatments; range, 1 - 11 treatments).
Two of the 144 patients did not receive a second systemic therapy prior to evaluation at our center, so PFS could be calculated for the remaining 142 patients. The PFS from tx_n to tx_n+3 was significantly decreased (p = 0.001850) (Figure 1). Few advanced cancers have more than four lines of FDA-approved or consensus guidelines recommendations for systemic therapy, thus we examined the time to progression of the first five treatments (p = 2.938e-07) (Figure 2)."