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Blogger's Note: two specific references to ovarian cancer - MS (multiple sclerosis)/ovarian cancer; paraneoplastic syndromes/ovarian cancer;
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open access: Multiple Associations Between a Broad Spectrum of Autoimmune Diseases, Chronic Inflammatory Diseases and Cancer
Background: Many recent studies suggest
the immune system plays a significant role in the pathogenesis of
autoimmune diseases,
chronic inflammatory diseases, and cancer.
Materials and Methods: Literature published between 2001 and 2011 was
reviewed
for risk of cancer development in patients with
autoimmune and chronic inflammatory diseases. Mode of risk assessment
employed
did not limit inclusion of studies. Autoimmune
conditions developing after diagnosis of a pre-existing cancer were also
considered.
Results: We report a pervasive, largely positive
association between 23 autoimmune and inflammatory diseases and
subsequent
cancer development. We discuss associations for
celiac disease, inflammatory bowel disease rheumatoid arthritis,
systemic
lupus erythematosus, and multiple sclerosis in
detail. We also address the less frequently reported development of some
autoimmune
conditions within the course of some malignancies,
such as vitiligo developing in the course of melanoma. Conclusion:
Evidence
demonstrates that chronic inflammation and
autoimmunity are associated with the development of malignancy.
Additionally, patients
with a primary malignancy may develop autoimmune
like disease. These relationships imply a need for surveillance of
patients
on immunomodulatory therapies for potential
secondary disease processes.
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