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Is there any association between retroperitoneal lymphadenectomy and survival benefit in advanced stage epithelial ovarian carcinoma patients?
Abstract
Aim:
The effect of systematic retroperitoneal lymphadenectomy (SRL) remains
controversial in patients with advanced epithelial ovarian cancer (aEOC)
who are optimally debulked.
Conclusion: Our data suggest that aEOC patients with optimal cytoreduction who underwent SRL did not show a significant improvement in survival irrespective of each histological type.
Conclusion: Our data suggest that aEOC patients with optimal cytoreduction who underwent SRL did not show a significant improvement in survival irrespective of each histological type.
Material and Methods:
Demographic and clinicopathologic data were obtained from the Tokai
Ovarian Tumor Study Group between 1986 and 2009. All patients were
divided into two groups. Group A (n = 93): (i) patients did not undergo SRL; and (ii) lymph node exploration or sampling was optional. Group B (n = 87):
patients underwent SRL. Survival curves were calculated using the
Kaplan–Meier method. Differences in survival rates were analyzed using
the log–rank test.
Results: All
pT3–4 aEOC patients were optimally debulked (residual tumor <1 cm).
The median age was 55 years (range: 18–84). The 5-year progression-free
survival (PFS) rates of groups A and B were 46.7 and 41.9%, respectively
(P = 0.658). In addition, the 5-year overall survival (OS) rates were 62.9 and 59.0%, respectively (P = 0.853).
Subsequently, there was no significant difference in OS and PFS in the
two groups stratified to histological type (serous or non-serous type).
Furthermore, there was no significant difference in recurrence rates in
retroperitoneal lymph nodes regardless of completion of lymphadenectomy.
Conclusion:
Our data suggest that aEOC patients with optimal cytoreduction who
underwent SRL did not show a significant improvement in survival
irrespective of each histological type.
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