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Two-marker Combinations for Preoperative Discrimination of Benign and Malignant Ovarian Masses
Abstract
Background:
When caring for patients with
ovarian neoplasms, correct preoperative discrimination of benign and
malignant disease
is deemed vital. In this study, we tested serum
biomarkers' alone and in combination, to achieve this aim.
Conclusion:
Materials and
Methods:
We measured the concentrations of Cancer Antigen
(CA)-125, CA15-3, CA27-29, Carcinoembryonic Antigen (CEA), CA19-9, human
chorionic gonadotropin (hCG), Placental Protein
(PP)1490, CA72-4, galectin-3, galectin-1 and Human epididymis protein
(HE)4
in sera of 133 patients with pelvic masses by ELISA
and correlated the results to subsequent histology.....
Results:
The best single biomarkers were CA-125
(sensitivity and AUC) and HE4 (specificity). Combinations with HE4 and
CA19-9
improved the predictive power of CA-125. The best
discrimination was achieved by the combination of CA-125 and HE4, with
an
AUC of 0.961.
Conclusion:
A combination of CA-125
with HE4 could facilitate the identification of women at risk for
ovarian
cancer.
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