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Gynecologic Oncology - Video-assisted thoracic surgery (VATS) evaluation of intrathoracic disease in patients with FIGO III and IV stage ovarian cancer
Abstract
Introduction
The
aim of this study was to assess the influence of video-assisted
thoracic surgery (VATS) on our treatment decisions in FIGO III and IV
ovarian cancer patients.
Highlights
►
Preoperative chest CTs is not an appropritate staging tool for the
evaluation of intrathoracic tumorload in advanced Ovarian Cancer
patients
► Video-assisted thoracic surgery can be performed quickly and safely before deciding about primary cytoreduction or neodadjuvant chemotherapy in advanced Ovarian Cancer patients
► Video-assisted thoracic surgery can be performed quickly and safely before deciding about primary cytoreduction or neodadjuvant chemotherapy in advanced Ovarian Cancer patients
Methods and patients
Patients
with ovarian cancer and suspected supra-diaphragmatic involvement
(pleural effusions, pleural carcinomatosis, lung metastasis, or enlarged
supra-diaphragmatic lymph nodes) at chest computer tomography (CT) scan
underwent VATS with or without laparoscopy (LSC) to decide for primary
cytoreduction or neoadjuvant chemotherapy. Operation time, VATS
complications (intrapleural hematoma, secondary hemorrhage with
intervention, pneumonia, empyema) and shift in the therapeutic strategy
due to VATS were evaluated.
Results
17
patients were included into this study (1 patient with FIGO stage IIIb,
1 with IIIc and 15 with stage IV). The median operation time for VATS
only was 46.5 minutes (range: 20 – 50 min, n = 3). Perioperatively, no
complications occurred. After surgical staging, the tumor was confined
to the abdomen in four patients in whom primary cytoreduction was
attempted. All other 13 patients underwent neoadjuvant chemotherapy.
VATS altered the therapeutic management in 6/17 ovarian cancer patients
(3 times upstaging, 3 times downstaging). Negative predictive values
(NPV) for local and diffuse pleural carcinomatosis ranged between 0.5
and 0.71.
Discussion
In
this case series, VATS in addition to LSC showed negligible morbidity
related to surgery and a short operation time. We were able to improve
the accuracy of the FIGO staging and assessed operability more reliably
in these patients than through imaging techniques alone.
Highlights
►
Preoperative chest CTs is not an appropritate staging tool for the
evaluation of intrathoracic tumorload in advanced Ovarian Cancer
patients ► Video-assisted thoracic surgery can be performed quickly and
safely before deciding about primary cytoreduction or neodadjuvant
chemotherapy in advanced Ovarian Cancer patients
Keywords
- Ovarian cancer;
- Thoracic staging;
- Video assisted thoracic surgery
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