Ovarian cancer: emerging molecular-targeted therapies

Review

Authors: Sourbier C

Published Date June 2012 Volume 2012:6 Pages 147 - 154

DOI: http://dx.doi.org/10.2147/BTT.S24155

Carole Sourbier

Rockville, MD, USA

Abstract: With about 22,000 new cases estimated in 2012 in the US and 15,500 related deaths, ovarian cancer is a heterogeneous and aggressive disease. Even though most of patients are sensitive to chemotherapy treatment following surgery, recurring disease is almost always lethal, and only about 30% of the women affected will be cured. Thanks to a better understanding of the molecular mechanisms underlying ovarian cancer malignancy, new therapeutic options with molecular-targeted agents have become available. This review discusses the rationale behind molecular-targeted therapies and examines how newly identified molecular targets may enhance personalized therapies for ovarian cancer patients. 

http://www.dovepress.com/ovarian-cancer-emerging-molecular-targeted-therapies-peer-reviewed-article-BTT