Height, weight, BMI and ovarian cancer survival

Height, weight, BMI and ovarian cancer survival

Publication year: 2012
Source:Gynecologic Oncology, Volume 127, Issue 1
Joanne Kotsopoulos, Joel R.K. Moody, Isabel Fan, Barry Rosen, Harvey A. Risch, John R. McLaughlin, Ping Sun, Steven A. Narod
Objectives Ovarian cancer is a highly fatal gynecologic malignancy. Prognosis is primarily based on clinicopathologic features. There is interest in the role of modifiable factors including overweight and obesity, although data to date have been inconclusive. Here we evaluate the relationship between body size and ovarian cancer survival among 1423 women diagnosed with epithelial ovarian cancer in a large population-based study. Methods Information on risk factors and characteristics was collected by telephone. Vital status was determined both by computerized record-linkage and by chart review. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for height, weight and body mass index (BMI) in association with ovarian cancer-specific mortality. Results Height, weight and BMI 5years prior to diagnosis did not significantly predict ovarian cancer survival in this study. The HR for ovarian cancer-specific mortality for women with a weight of >61kg compared with >50–55kg was 0.91 (95%CI 0.71–1.20). The HR among women with a BMI≥30kg/m² compared to 18.5– <25kg/m² was 1.11 (95%CI 0.87–1.42). These findings did not vary by histologic subtype. Conclusions Our results do not support a role of height, adult weight or adiposity in ovarian cancer prognosis.

Highlights

► The role of modifiable host factors including overweight and obesity on ovarian cancer prognosis is not clear. ► We evaluated the relationship between body size and ovarian cancer survival among 1423 women diagnosed with epithelial ovarian cancer. ► Our results do not support a role of height, weight or adiposity in ovarian cancer prognosis.

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