European Association of Urology 2012: Guidelines on Upper Urinary Tract Urothelial (re: Lynch Syndrome)

http://www.uroweb.org/gls/pdf/06_UUTUCC.pdf

"....There are familial/hereditary cases of UUT-UCCs linked to (Lynch Syndrome) hereditary nonpolyposis colorectal
carcinoma (HNPCC) (14). Among patients with UUT-UCCS, these cases can be detected during a medical
interview. Indeed, the cancer is likely to be hereditary if the patient is < 60 yr of age and/or has a personal or
family history of an HNPCC-type cancer (15,16). These patients should undergo DNA sequencing to identify
hereditary cancers that have been misclassified as sporadic cancers by insufficient clinical data. The presence
of other HNPCC-associated cancers should also be evaluated. These patients should be closely monitored,
and genetic counselling is advocated (15,16)......"