Akt-activated endothelium constitute the niche for residual disease and resistance to bevacizumab in ovarian cancer Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Wednesday, October 24, 2012

Akt-activated endothelium constitute the niche for residual disease and resistance to bevacizumab in ovarian cancer



Akt-activated endothelium constitute the niche for residual disease and resistance to bevacizumab in ovarian cancer


Conclusion: Our data highlights the role of an activated endothelium in the constitution of the residual disease and resistance to bevacizumab. These results hint on the concept of using combination therapy to override drug resistance in ovarian cancer and to suppress or eradicate residual disease.


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