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Plasma concentrations of the vitamin E-binding protein afamin are associated with overall and progression-free survival and platinum sensitivity in serous ovarian cancer – A study by the OVCAD consortium
Abstract
Objective
Comparative
proteomics identified the plasma protein afamin (link to google search for 'afamin') as potential biomarker
for ovarian cancer (OC). Significantly decreased afamin plasma
concentrations in pre-therapeutic OC patients reconstituted to control
values after successful tumor surgery. This study evaluates the
association of afamin with survival and response to therapy in serous OC
patients within the OVCAD consortium project.
Conclusion
These data indicate that afamin is associated with therapy response and survival rate in advanced OC patients.
Highlights
►
The plasma protein afamin is evaluated as prognostic tumor marker for
ovarian cancer
► Afamin plasma concentrations are associated with response to therapy and survival
► Afamin may therefore serve as therapy monitoring for estimation of disease progression
► Afamin plasma concentrations are associated with response to therapy and survival
► Afamin may therefore serve as therapy monitoring for estimation of disease progression
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