Predicting PARP inhibitor sensitivity and resistance

Predicting PARP inhibitor sensitivity and resistance: Comment on: Oplustilova L, et al. Cell Cycle 2012; 11:3837-50.

 "The concept of precision therapy in cancer implies an ability to customize treatment according to the molecular makeup of the patient and the tumor. While many pharmaceutical agents are described as targeted therapies, their precise role in cancer treatment is unclear. Often the new drug’s target is well-described, but the precise indication of when it should be used (i.e., a prospectively validated predictive marker) is often not defined. PARP inhibitors exemplify this paradigm well............