open access: Cancer stem cells, tumor dormancy, and metastasis | Frontiers in Cancer Endocrinology

Frontiers | Cancer stem cells, tumor dormancy, and metastasis | Frontiers in Cancer Endocrinology

Introduction

Solid tumors account for the major cancer burden, and epithelial cancers arising in breast, lung, colon, prostate, and ovary comprise approximately 80% of all cancers (Visvader and Lindeman, 2008). However, over 90% of mortality in cancer patients is attributed to the subsequent spread of cancer cells to distant tissues....