open access: Primary Human Ovarian Epithelial Cancer Cells Broadly Express HER2 at Immunologically-Detectable Levels

PLOS ONE: Primary Human Ovarian Epithelial Cancer Cells Broadly Express HER2 at Immunologically-Detectable Levels

 "We conclude that HER2 is broadly expressed in established and primary ovarian carcinomas. Despite the wide range of HER2 expression, all OvCas were sensitive to recognition by genetically modified T cells bearing an anti-HER2 CAR indicating that the surface expression of HER2 is sufficient for the induction of potent immune responses. We postulate that HER2-directed immunotherapeutic strategies may have beneficial effects in patients with ovarian carcinoma, including many of those who are negative according to routinely applied immunohistochemistry on tumors resected at primary surgery. However, careful design and testing is needed to understand how to safely apply HER2 targeted approaches for the treatment of patients with HER2-expressing ovarian carcinomas."