Upper urinary tract carcinoma in Lynch syndrome cases. [J Urol. 2011] - PubMed - NCBI
Source
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA. david.crockett@unmc.edu
Abstract
PURPOSE:
Patients
with Lynch syndrome are much more likely to have generally rare upper
urinary tract urothelial carcinoma but not bladder urothelial carcinoma.
While the risk has been quantified, to our knowledge there is no
description of how this population of patients with Lynch syndrome and
upper urinary tract cancer differs from the general population with
upper urinary tract cancer.
RESULTS:
Of the patients with Lynch syndrome 91%
had mutations in MSH2 rather than in MSH1 and 79% showed
upper tract
urothelial carcinoma a mean of 15.85 years after prior Lynch
syndrome-type cancer. Median age at diagnosis was 62 years vs 70 in the
general population (p <0.0001). Only half of our patients had a
significant smoking history and the male-to-female ratio was 0.95.
Of
patients with Lynch syndrome 51% had urothelial carcinoma in the ureter
while it occurred in the renal pelvis in 65% of the general population
(p = 0.0013). Similar numbers of high grade tumors were found in the
Lynch syndrome and general populations (88% and 74%, respectively, p =
0.1108).
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