Abstract
The aim of this study was to investigate the
clinicopathologic features, treatment and outcome of seven patients with
an ovarian Sertoli-Leydig cell tumor (SLCT). Five patients presented
with feminization, two with accompanying virilization. One presented
with amenorrhea alone. Three of the five patients showing feminization
symptoms had endocrine-related diseases. Histologically, five tumors
were well differentiated, the other two were poorly differentiated. The
latter two patients were misdiagnosed as having an ovarian epithelial
carcinoma or granulosa cell tumor from frozen sections.
Immunohistochemistry showed that the tumors were calretinin-positive in
two patients and one was inhibin-positive. Four patients underwent total
abdominal hysterectomy and bilateral salpingo-oophorectomy(TAH/BSO) and
two were treated by unilateral salpingo-oophorectomy. Among them, two
patients received adjuvant chemotherapy. Six patients were free of
disease in a follow-up of 2-34 years and one achieved a pregnancy. The
remaining patient recurred 4 years later. Feminization as well as
virilization might provide important clues for a preoperative diagnosis.
Histological misdiagnosis is probable in poorly differentiated tumors.
Conservative surgery including retention of fertility can be considered.
However, the tendency for recurrence in poorly differentiated tumors
should be considered.
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