A prospective study of quality of life in patients undergoing pelvic exenteration: Interim results

 Blogger's Note/Opinion: based on the limited information provided in the abstract it is noteworthy of the #'s included in the table (original accrual # etc...; while awaiting further information it would seem conclusions maybe overly optimistic??))

A prospective study of quality of life in patients undergoing pelvic exenteration: Interim results

Abstract

Objective

Little prospective data exist on quality of life (QOL) after pelvic exenteration (PE). This ongoing study prospectively examines the QOL changes following this radical procedure using a comprehensive battery of psychological instruments.

Methods

Since 2005, enrolled patients were interviewed (EORTC QLQ-C30, EORTC QLQ-CR38, EORTC QLQ-BLM30, BFI, BPI-SF, IADL, CES-D, IES-R) preoperatively and at 3, 6, and 12 months after PE for physical/psychological symptoms. Data were examined using repeated measure ANOVA.

Results

Sixteen women (3 anterior, 1 posterior, and 12 total PEs), with more than 1 year of follow-up, completed all scheduled interviews. Median age was 58 years (range, 28–76 years). Overall QOL (F = 6.3, p < 0.02), ability to perform instrumental daily activities (F = 6.8, p < 0.02), body image (F = 11.9, p < 0.00), and sexual function (F = 8.0, p < 0.01) all declined at 3 months but were near baseline by 12 months after PE. Although, overall, physical function followed a similar trend (F = 14.8, p < 0.00), it did not return to baseline. At the 12-month interview, patients reported increased gastrointestinal symptoms (F = 8.9, p < 0.01) but significantly less stress-related ideation (F = 6.1, p < 0.03) compared to baseline. Pain levels did not change significantly during the study period (F = 0.4, p < 0.74).

Conclusions

Although patients report lingering gastrointestinal symptoms and some persistent decline in physical function after PE, most adjust well, returning to almost baseline functioning within a year. Providers can counsel patients that many, though not all, symptoms in the first 3 months following exenteration are likely to improve as they adapt to their changed health status. These preliminary results await confirmation of a larger analysis.

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Highlights

► This ongoing prospective study examines quality of life (QOL) in patients undergoing pelvic exenteration (PE).
► An extensive battery of psychological measures is used to assess multiple QOL endpoints relevant to these patients.
► Despite some persistent decline in physical function and lingering gastrointestinal symptoms, in general, QOL recovers within a year after PE.

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Figures and tables from this article:

Fig. 1. Patient participation.