High impact of FDG-PET/CT in diagnostic strategies for ovarian cancer

High impact of FDG-PET/CT in diagnostic strategies for ovarian cancer

1. ¹Radiology Department, Faculty of Medicine, Menoufiya University, Egypt
2. ²PET Center, Dokkyo Medical University, Japan
3. ³Medical Imaging Sciences and Biostatistics Departments, Al-Ghad International Colleges of Health Sciences, Saudi Arabia

Abstract

Background Ovarian cancer has the highest mortality of all gynecologic malignancies. FDG-PET/CT was proven to be accurate for identification of primary ovarian tumors, regional lymph nodes, and distant metastases.

Purpose To evaluate ovarian masses at FDG-PET/CT in correlation with histopathologic findings.

Material and Methods Ninety-eight patients underwent whole body FDG-PET/CT examination. Eighty-six patients with primary ovarian cancer and 12 patients with metastatic disease to the ovaries were included.

Results PET/CT imaging was true-positive in 87/94 patients with malignant tumors. In 4/4 patients with benign tumors, PET/CT results were true-negative, with sensitivity of 92.6%, specificity 100%, total test accuracy 92.9%. Fifty-seven patients were diagnosed as stage IV ovarian cancer with distant metastasis.

Conclusion The anatomical/functional examination by FDG-PET/CT was proven to be valuable in increasing the diagnostic accuracy that can help improve patient management.