open access: Diagnostic Value of Human Epididymis Protein 4 Compared with Mesothelin for Ovarian Cancer: a Systematic Review and Meta-analysis

SMRP = soluble mesothelin-related protein (SMRP); note limitations of analysis as indicated in the paper

Diagnostic Value of Human Epididymis Protein 4 Comparedwith Mesothelin for Ovarian Cancer: a Systematic Review andMeta-analysis


"The current meta-analysis results showed that the
diagnostic accuracy of HE4 to differentiate ovarian
cancer from benign gynecologic diseases was better than
that of SMRP. The combination of two or more tumor
markers seems to be more sensitive and specific. Based
on the gathered data, the serum tumor marker CA-125,
in combination with HE4 or SMRP, can be used to help
predict the presence of malignancies in patients with a
pelvic mass."