open access: Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium

 Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium

"...Several key non-genetic risk factors for ovarian cancer were reported in the early 1990s, when studies established decreased risks associated with oral contraceptive use [10,11], parity [12,13] and breast-feeding [12]. Using our consortium data, we recently reported that endometriosis was associated with increased risk of endometrioid and clear cell ovarian
carcinomas [23]. However, few modifiable risk factors for ovarian cancers have been found.
Perhaps the only lifestyle factor that is most consistently associated with modified risk of ovarian cancers is smoking, which is associated with an increased risk of both mucinous ovarian carcinoma and mucinous borderline tumors [24,25]. This emphasizes the importance
of, and the need for more, pooled analyses of individual-level data that are harmonized carefully across different studies through collaborations within consortia, such as OCAC.
Clearly, the research community struggles to understand the causes of the majority of these elusive and deadly cancers...."


Conclusions
We found no evidence that recent moderate alcohol drinking is associated with increased risk for overall OC, or that variation in risk is associated strongly with specific histologic types.
Understanding modifiable causes of these elusive and deadly cancers remains a priority for the research community