open access: Update on first-line treatment of advanced ovarian carcinoma Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Friday, January 25, 2013

open access: Update on first-line treatment of advanced ovarian carcinoma



Update on first-line treatment of advanced ovarian carcinoma

 
Dovepress Journal: International Journal of Women's Health


Abstract: 
Despite the high response rate to first-line treatment of advanced ovarian cancer, the vast majority of patients relapse. Maximal debulking surgery and chemotherapy with a platinum doublet have remained the standard of care for many years and new approaches are imperative. Recent clinical trials have given grounds for hope. Neoadjuvant chemotherapy, intraperitoneal delivery, and dose-dense strategies have all shown promising results, as has the targeting of angiogenesis. A greater understanding of the molecular landscape of ovarian cancer is helping to identify new treatment options. In this review, we will highlight the key trials and recent progress in these areas.




 

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