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The Value of 18F-FDG PET/CT in recurrent gynecologic malignancies prior to pelvic exenteration
Results
33
patients(mean age 56 years,range:28–81) were included; primary sites of
disease were the cervix (n = 18), uterus (n = 8) and vagina/vulva
(n = 7). AUCs for organ invasion ranged from 0.74-0.96. There was a
significant association between FDG uptake metrics incorporating tumor
volume (TLG and MTV) and OS (p ≤ 0.001) as well as between MTV and PFS
(p = 0.001). No significant association was identified between SUVmax
and OS/PFS (p = 0.604/0.652). Inter-reader agreement for organ invasion
was fair to substantial (k = 0.36-0.74) and almost perfect for FDG
quantification (ICC = 0.97-0.99).
Conclusion
In patients undergoing pelvic exenteration for recurrent gynecological malignancies, 18 F-FDG
PET/CT is useful for preoperative assessment of disease extent.
Furthermore, quantitative metrics of FDG uptake incorporating MTV serve
as predictive biomarkers of progression-free and overall survival in
this population.
Highlights
►
18 F-FDG PET/CT had high accuracy for the evaluation of disease extent
prior to pelvic exenteration for recurrent gynecological cancer.
► Quantitative FDG uptake metrics incorporating tumor volume (total lesion glycolysis and metabolic tumor volume) are significantly associated with overall survival.
► No significant association was identified between SUVmax and overall survival.
► Quantitative FDG uptake metrics incorporating tumor volume (total lesion glycolysis and metabolic tumor volume) are significantly associated with overall survival.
► No significant association was identified between SUVmax and overall survival.
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