OPEN ACCESS: Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts -- Vasen et al. -- Gut

 Published Online First 13 February 2013

Blogger's Note: reference gyn cancers including prophylatic surgery/primary peritoneal eg. per selected examples quote; read full paper full scope

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"Question no 3

How effective is surveillance for endometrial and ovarian cancer?

Relevant literature

In LS, the risk of developing EC is very high and equals or even exceeds the risk of CRC in female gene carriers.49".....

"....Since that review, another retrospective study was published on the impact of gynaecological screening in MSH2 carriers (n=54).57....

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Cancer of the urinary tract

"Many studies have reported an increased risk of urothelial cancers of the upper urinary tract in LS. Recent studies have also demonstrated an increased risk of bladder cancer.18 ,19 ,75 The estimated risk varies from 5% to 20%, with the highest risk in male carriers and those with an MSH2 mutation. The risk for non-urothelial tumours was not increased.

The classic presenting sign of urothelial tumours is haematuria (hematuria) without pain.......

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open access:  Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts -- Vasen et al. -- Gut