Diagnostic accuracy of Risk of Malignancy Index in predicting complete tumor removal at primary debulking surgery for ovarian cancer patients

Diagnostic accuracy of Risk of Malignancy Index in predicting complete tumor removal at primary debulking surgery for ovarian cancer patients - Fagö-Olsen - Acta Obstetricia et Gynecologica Scandinavica - Wiley Online Library

Abstract

Ovarian cancer patients, in whom complete tumor removal is impossible with primary debulking surgery (PDS) may benefit from neoadjuvant chemotherapy and interval debulking surgery. However, the task of performing a pre-operative evaluation about the feasibility of PDS is difficult. We aimed to investigate if risk of malignancy index (RMI) was a useful marker for this evaluation. RMI and surgical outcome were investigated in 164 patients, of whom 49 had no residual tumor after PDS. Receiver operating characteristic showed an area under the curve of 0.72 (confidence interval: 0.64–0.80). The possibility of complete tumor removal decreased with increasing RMI and there was a tendency towards higher RMI in patients with residual tumor after PDS, but no single cut-off value of RMI produced useful clinical predictive values. In conclusion, RMI alone is not an optimal method to determine if complete tumor removal is possible with PDS.