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Abstract
Objective
To
compare primary debulking surgery (PDS) vs. neoadjuvant chemotherapy
with interval debulking surgery (NACT-IDS) among elderly patients with
ovarian/fallopian tube/primary peritoneal carcinoma.
Methods
Medical
records of patients ≥ 70 years old with epithelial ovarian/fallopian
tube/primary peritoneal carcinoma between January 2000 and December 2010
were reviewed. Patients were separated by PDS or NACT-IDS. Preoperative
characteristics, surgical procedures and postoperative and oncologic
outcomes were compared. Surgical procedures were given a complexity
score based on a previously published method.
Results
Of
165 patients, 125 (75.8%) underwent PDS and 40 (24.2%) underwent
NACT-IDS. Patients undergoing NACT-IDS were more likely to have a
pleural effusion (without cytology) and stage 4 disease. Median CA-125
at diagnosis was greater for those undergoing NACT-IDS. The NACT-IDS
group was associated with less intraoperative blood loss (250 vs.
400 mL, p = 0.001), a greater chance of achieving no residual disease
(40% vs. 16%, p = 0.005) and a shorter hospital length of stay (LOS) (5
vs. 7 days, p < 0.001). PFS (17 vs. 15 months, p = 0.708) and OS (29
vs. 33 months, p = 0.827) were similar between the two groups.
Readmission rates within 30 days of surgery were greater in those
undergoing PDS (17.6% vs. 2.5%, p = 0.016). After readmission, the
median hospital LOS was 6 days (range: 1–41).
Conclusions
Elderly
patients undergoing PDS have similar oncologic outcomes when compared
to patients undergoing NACT-IDS. The risk of readmission within 30 days
of surgery is significantly greater among patients undergoing PDS.
Highlights
►
Elderly patients undergoing either PDS or NACT-IDS have similar
oncologic outcomes.
► The risk of readmission within 30 days of surgery is significantly greater among patients undergoing PDS.
► The risk of readmission within 30 days of surgery is significantly greater among patients undergoing PDS.
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