(Lynch Syndrome) Are the common genetic variants associated with colorectal cancer risk for DNA mismatch repair gene mutation carriers?

Blogger's Note:  while this pertains to Lynch Syndrome, we need to be reminded that specific and targeted research is still in very early stages (human genome)

Abstract:

Background

Genome-wide association studies have identified at least 15 independent common genetic variants associated with colorectal cancer (CRC) risk. The aim of this study was to investigate whether 11 of these variants are associated with CRC risk for carriers of germline mutations in DNA mismatch repair (MMR) genes.

Conclusions

We found no evidence that the SNPs associated with CRC in the general population are modifiers of the risk for MMR gene mutation carriers overall, and therefore any evidence of proven clinical utility in Lynch syndrome.

Keywords: Genetic variant, Colorectal cancer, Lynch syndrome, Mismatch repair