open access: Colorectal and Other Cancer Risks for Carriers and Noncarriers From Families With a DNA Mismatch Repair Gene Mutation: A Prospective Cohort Study (Canada/U.S./Australia)

Blogger's Note/Opinion: previously posted in abstract form, now open access; also discusses breast cancer in Lynch Syndrome and pancreatic cancer; the lack of pancreatic screening/advocacy in this particularly deadly cancer has not changed in decades and the philosophy remains

JCO

"An unanticipated finding of our study is the confirmation of an
increased risk for cancers of the breast and pancreas for MMR gene
mutation carriers. Although risk of pancreatic cancer has been investigated in Lynch syndrome,29-33 the evidence was inconsistent. The study showing evidence for an association was that of Kastrinos et al,34 which recently showed an increased risk of pancreatic cancer in Lynch syndrome (hazard ratio, 8.6; 95% CI, 4.5 to 15.7). This result is consistent with our finding (test for difference, P .79). However, given
the limited evidence for efficacy of screening for pancreatic cancers,35
expert opinion has not yet advocated pancreatic cancer screening in
the context of Lynch syndrome."