open access: Lynch syndrome related endometrial cancer: clinical significance beyond the endometrium

open access

"....Recently, focus has shifted to LS-related endometrial cancer (EC) as women with LS have a 40-60% chance of presenting with EC as the first clinical manifestation....

"...It is interesting to note that LS-related EC sometimes is accompanied (synchronous, or metachronous) by LS-related ovarian cancer. In fact in LS, the lifetime risk for endometrial cancer is 40-60%, and for ovarian cancer, 9-12% [19]. The latter is usually clear cell carcinoma and can present independently and less frequency [4,20]. Compared to LS-related EC cases, LS-related ovarian cancer tends to have a higher MSH2 mutation rate and occurs in a younger age, average of 45 years old [21]......