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Article
" There are 18 members of the PARP family of
proteins, but therapeutic effect of PARPi on cancer cells is observed only in conjunction with DNA damage;
hence DNA damage-responsive PARPs are the most
Conclusion
In cancer
treatment with PARPi, the personalization of therapy is important because many
factors can influence the efficiency of PARPi, such as HR and NHEJ status,
PARP-1 levels or its activity and finally other factors that influence
intracellular concentrations of PARPi. Therefore, it would be necessary to
assess the status of these controlling factors before beginning the treatment
with PARPi (Lord and Ashworth, 2012; Ratner et al., 2012). A thorough understanding of
different mechanisms for the resistance to PARPi will permit us to design
better PARPi monotherapy as well as combination therapy, and will allow us to
identify conditions that can re-sensitize tumor cells to PARPi; and thus treat
cancer patients more efficiently.
There are
18 members of the PARP family of proteins, but therapeutic effect of
PARPi on cancer cells is observed only in conjunction with DNA damage;
hence DNA damage-responsive PARPs are the most likely mediators of PARPi
effect. - See more at:
http://www.frontiersin.org/Pharmacology_of_Anti-Cancer_Drugs/10.3389/fphar.2013.00018/full#sthash.wXwDkNj1.dpuf
There are
18 members of the PARP family of proteins, but therapeutic effect of
PARPi on cancer cells is observed only in conjunction with DNA damage;
hence DNA damage-responsive PARPs are the most likely mediators of PARPi
effect. - See more at:
http://www.frontiersin.org/Pharmacology_of_Anti-Cancer_Drugs/10.3389/fphar.2013.00018/full#sthash.wXwDkNj1.dpuf
There are
18 members of the PARP family of proteins, but therapeutic effect of
PARPi on cancer cells is observed only in conjunction with DNA damage;
hence DNA damage-responsive PARPs are the most likely mediators of PARPi
effect. - See more at:
http://www.frontiersin.org/Pharmacology_of_Anti-Cancer_Drugs/10.3389/fphar.2013.00018/full#sthash.wXwDkNj1.dpuf
There are
18 members of the PARP family of proteins, but therapeutic effect of
PARPi on cancer cells is observed only in conjunction with DNA damage;
hence DNA damage-responsive PARPs are the most likely mediators of PARPi
effect. - See more at:
http://www.frontiersin.org/Pharmacology_of_Anti-Cancer_Drugs/10.3389/fphar.2013.00018/full#sthash.wXwDkNj1.dpuf
There are
18 members of the PARP family of proteins, but therapeutic effect of
PARPi on cancer cells is observed only in conjunction with DNA damage;
hence DNA damage-responsive PARPs are the most likely mediators of PARPi
effect. - See more at:
http://www.frontiersin.org/Pharmacology_of_Anti-Cancer_Drugs/10.3389/fphar.2013.00018/full#sthash.wXwDkNj1.dpuf
ere are
18 members of the PARP family of proteins, but therapeutic effect of
PARPi on cancer cells is observed only in conjunction with DNA damage;
hence DNA damage-responsive PARPs are the most likely mediators of PARPi
effect. - See more at:
http://www.frontiersin.org/Pharmacology_of_Anti-Cancer_Drugs/10.3389/fphar.2013.00018/full#sthash.wXwDkNj1.dpuf
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