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Abstract
Objective
Serial
sectioning of the fallopian tube in women undergoing risk reducing
surgery has been shown to increase the detection rate of occult
malignancy in BRCA mutation carriers. We undertook this study to
determine whether this protocol at the time of surgery for ovarian
cancer (OV) or primary peritoneal malignancies (PP) changes the
detection rate of fallopian tube carcinoma (FT). We secondarily
investigated where this difference affects patient outcomes.
Methods
A
retrospective review of 130 patients treated at the University of
Chicago Medical Center for ovarian, peritoneal or fallopian tube
carcinoma was conducted. Sixty five patients diagnosed with OV, PP or FT
who had serial sectioning of the fallopian tubes at the time of
diagnoses (SS) were compared to 65 patients whose fallopian tubes were
sectioned in a standard fashion (PSS).
Results
Serial
sectioning of the fallopian tube at the time of pathologic examination
in women with presumed OV or PP led to an increase in the number of
women diagnosed with FT as the primary site of origin (p < 0.001).
Clinical or pathologic risk factors leading to an increased risk of FT
were not identified. Survival between the two groups was similar.
Conclusion
In
women with presumed OV or PP, serial sectioning identifies women with
FT. FT may be more common than previously noted; however distinct
biologic or clinical behavior to differentiate it from OV or PP could
not be identified. Clinical management of FT should continue to be the
same as that of OV or PP.
Highlights
►
Serial sectioning of the fallopian tube identifies a greater number of
malignancies originating in the fallopian tube.
► There is no difference in outcomes between ovarian, fallopian tube or primary peritoneal carcinomas.
► There is no difference in outcomes between ovarian, fallopian tube or primary peritoneal carcinomas.
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