Short-term single treatment of chemotherapy results in the enrichment of ovarian cancer stem cell-like cells leading to an increased tumor burden (in mice)

Blogger's Note: in mice

open access

"... These results suggest that a short-term single treatment of chemotherapy leaves residual cells that are enriched in CSClike (cancer stem cell) traits, resulting in an increased metastatic potential. The novel findings in this study are important in understanding the early molecular mechanisms by which chemoresistance and subsequent relapse may be triggered after the first line of chemotherapy treatment...."