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Abstract
Objective
Polymorphisms
in the vitamin D receptor (VDR) gene have been shown in some studies to
be associated with the risk of epithelial ovarian cancer (EOC) in
Caucasian women. There are no published reports among African Americans.
Methods
Case–control
data from the North Carolina Ovarian Cancer Study were analyzed using
logistic regression to determine the association between seven VDR
polymorphisms and EOC in both Caucasians (513 cases, 532 controls) and
African Americans (74 cases, 79 controls). In a larger sample of
African–Americans (125 cases, 155 controls), we assessed associations
between six SNPs in proximity of rs7975232.
Results
African
American women who carried at least one minor allele of rs7975232 were
at higher risk for invasive EOC controlling for age and admixture with
an odds ratio (OR) for association under the log-additive model of 2.08
(95% confidence interval (CI) = 1.19, 3.63, p = 0.010). No association
was observed between any of the VDR variants and EOC among Caucasians. A
larger sample of African Americans revealed a nearly two-fold increased
risk of invasive EOC associated with rs7305032, a SNP in proximity to
rs7975232 (R2 = 0.369) with a log-additive OR of 1.87 (95% CI = 1.20, 2.93, p = 0.006).
Conclusions
This
is the first report showing VDR variants associated with ovarian cancer
risk in African American women. A larger study of African American
women is needed to confirm these findings. These results imply that
vitamin D exposure is a possible modifiable risk factor of ovarian
cancer among African Americans.
Highlights
►
The OR for the association between ovarian cancer and rs7305032 in the
VDR gene was 1.87 among African Americans.
► No association between VDR variants and ovarian cancer was detected among Caucasian women.
► This is the first report showing VDR variants associated with ovarian cancer risk in African American women.
► No association between VDR variants and ovarian cancer was detected among Caucasian women.
► This is the first report showing VDR variants associated with ovarian cancer risk in African American women.
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