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Abstract
Background:
Few
studies have attempted to characterise genomic changes occurring in
hereditary epithelial ovarian carcinomas (EOCs) and inconsistent results
have been obtained. Given the relevance of DNA copy number alterations
in ovarian oncogenesis and growing clinical implications of the
BRCA-gene status, we aimed to characterise the genomic profiles of
hereditary and sporadic ovarian tumours.
Conclusion:
Somatic
alterations occurring in the development of familial EOCs do not differ
substantially from the ones occurring in sporadic carcinomas. However,
some specific features like extensive genomic loss observed in BRCA1/2 tumours may be of clinical relevance helping to identify BRCA-related patients likely to respond to PARP inhibitors.
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