Abstract
Aim:
Our purpose was to analyze the tissue expression of human epididymis
protein-4 (HE4) in borderline tumors of the ovary (BOT) and to correlate
it with histological subtypes and clinical features.
PATIENTS AND METHODS:
Tumor
tissue samples from 25 patients with BOT were stained on tissue
microarrays. The percentage of stained tumor cells was represented by
grouped immunoreactivity scores (IRS) 0 to 4.
RESULTS:
The
median patient age was 47 (range=22-73) years. Tumors in most patients
(19/25) were staged-FIGO I and presented serous (52%) or mucinous (40%)
histology. HE4 immunoreactivity occurred exclusively within the tumor
cells. No association between grouped IRS and histological type, age,
CA125 and FIGO stage was found. Correlation between HE4 positivity cells
and HE4 IRS was significant (p<0.001).
CONCLUSION:
The
role of HE4 in BOT remains unclear. Multicenter surveys are needed to
more profoundly help in the understanding of the biological and clinical
features of BOT.
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