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article
"Steven Narod’s latest Countercurrents contribution to
Current Oncology
discusses a new breast and ovarian cancer susceptibility gene known as
PPM1D
1. In this accompanying editorial, we put this exciting new finding in context.
MOSAICISM: WHAT IS IT AND HOW DOES IT HAPPEN?
Genetic mosaicism, as the name implies, indicates that the person is a
mosaic—that is, composed of more than one genotype. At the time of
diagnosis, all cancer patients are mosaics. They are mosaics because
they comprise at least two distinct genomes: the genome they were born
with, and the genome that they unwillingly acquired as a result of the
initiation and growth of cancer. In fact, as discussed next, it may be
that all humans are mosaics—but that some of us are more mosaic than
others......
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