open access: JAMA - Effect of Duloxetine on Pain, Function, and Quality of Life Among Patients With Chemotherapy-Induced Painful Peripheral NeuropathyA Randomized Clinical TrialDuloxetine and Chemotherapy-Induced Pain

open access


Importance  There are no known effective treatments for painful chemotherapy-induced peripheral neuropathy.

Objective  To determine the effect of duloxetine, 60 mg daily, on average pain severity.

Conclusion and Relevance  Among patients with painful chemotherapy-induced peripheral neuropathy, the use of duloxetine compared with placebo for 5 weeks resulted in a greater reduction in pain..........