open access
Abstract:
Tumor-infiltrating regulatory T cells (Tregs) promote immune evasion and
are associated with poor disease outcome in patients affected by
various malignancies. We have recently demonstrated that several,
inherited single nucleotide polymorphisms affecting Treg-related genes
influence the survival of ovarian cancer patients, providing novel
insights into possible mechanisms of immune escape......
April 16, 2013
Provisional Full-Text corresponds to the article as it appeared
upon acceptance. Fully formatted PDF and full text (HTML) versions
containing any author galley corrections will be made available soon.
When Provisional Full Text is displayed, it will always be open access.
Full Text
Despite considerable progresses in our understanding of the
factors that influence ovarian cancer progression, the survival rate of
patients affected by this deadly cancer has not yet appreciably
improved. Multiple factors influence patient survival in this setting,
including the histological subtype of the tumor, stage at diagnosis and
genetic predisposition.
1
It has become
clear that different histological subtypes of ovarian
cancer represent distinct diseases, bearing specific genetic lesions,
responding differently to chemotherapy and exhibiting dissimilar
survival rates.
Many studies have focused on serous ovarian cancers or
have grouped all other subtypes together, hence failing to take into
account the heterogeneous nature of the disease and obscuring
subtype-specific relevant results.1......
0 comments :
Post a Comment
Your comments?
Note: Only a member of this blog may post a comment.