Concordance Between the Findings of Epidemiological Studies and Randomized Trials in Nutrition: An Empirical Evaluation and Citation Analysis

Blogger's Note: a very extensive (long) paper trying to discern factors and results of  study findings in nutrition; numerous references to ovarian cancer as per search 'ovarian'

open access

Prepared for:
Agency for Healthcare Research and Quality
U.S. Department of Health and Human Services
540 Gaither Road
Rockville, MD 20850
www.ahrq.gov

"Understanding the translational paths that shape the evidence base may result in insights on why epidemiological and randomized data disagree or agree."

"It is unclear whether there is a good way to describe the maturity of the evidence base on an association between nutrients and outcomes. At a minimum, purely bibliometric approaches are not a good way to prioritize which nutrient exposures merit further study, and for which health outcomes."

Citations:

Koushik A, Hunter DJ, Spiegelman D, et al. Intake of the major carotenoids and the risk of epithelial ovarian cancer in a pooled analysis of 10 cohort studies. Int J Cancer. 2006 Nov 1;119(9):2148-54

Fairfield KM, Hankinson SE, Rosner BA, et al. Risk of ovarian carcinoma and consumption of vitamins A, C, and E and specific carotenoids: A prospective analysis. Cancer 2001;92:2318-26 [Abstract]. PMID: 11745286


Tworoger SS, Hecht JL, Giovannucci E, et al. Intake of folate and related nutrients in relation to risk of epithelial ovarian cancer. Am J Epidemiol. 2006 Jun 15;163(12):1101-11 [Abstract]. PMID: 16554344

Tworoger SS, Lee IM, Buring JE, et al. Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D and risk of incident ovarian cancer.Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):783-8 [Abstract]. PMID: 17416771

Genkinger JM, Hunter DJ, Spiegelman D, et al. Dairy products and ovarian cancer: a pooled analysis of 12 cohort studies. Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):364-72. PMID: 16492930

Kelemen LE, Sellers TA, Vierkant RA, et al. Association of folate and alcohol with risk of ovarian cancer in a prospective study of postmenopausal women. Cancer Causes Control 2004;15:1085-93. PMID: 15801492

Koushik A, Hunter DJ, Spiegelman D, et al. Intake of the major carotenoids and the risk of epithelial ovarian cancer in a pooled analysis of 10 cohort studies. Int J Cancer 2006;119:2148-54. PMID: 16823847

Pooling Project of Prospective Studies of Diet and Cancer, McCullough ML, Rodriguez C. Intake of the major carotenoids and the risk of epithelial ovarian cancer in a pooled analysis of 10 cohort studies. Int J Cancer 2006;119(9):2148-54. PMID:16823847

Thomson CA, Neuhouser ML, Shikany JM, et al. The role of antioxidants and vitamin A in ovarian cancer: results from the Women’s Health Initiative. Nutr Cancer 2008;60(6):710-9. PMID: 19005970


Larsson SC, Giovanucci E, Wolk A. Dietary folate intake and incidence of ovarian cancer: The Swedish Mammography Cohort. J Natl Cancer Inst 2004;96:396-402. PMID: 14996861