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open access
Review
Received: 2 April 2013; in revised form: 23 April 2013 / Accepted: 24 April 2013 / Published: 2 May 2013
Abstract: The
special class IIb histone deacetylase, HDAC6, plays a prominent role in
many cellular processes related to cancer, including oncogenesis, the
cell stress response, motility, and myriad signaling pathways. Many of
the lessons learned from other cancers can be applied to ovarian cancer
as well. HDAC6 interacts with diverse proteins such as HSP90, cortactin,
tubulin, dynein, p300, Bax, and GRK2 in both the nucleus and cytoplasm
to carry out these cancerous functions. Not all pro-cancer interactions
of HDAC6 involve deacetylation. The idea of using HDAC6 as a target for
cancer treatment continues to expand in recent years, and more potent
and specific HDAC6 inhibitors are required to effectively down-regulate
the tumor-prone cell signaling pathways responsible for ovarian cancer......
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