Simplifying clinical use of the genetic risk prediction model BRCAPRO -

Blogger's Note: this abstract refers to alternative BRCA genetic testing tools which brings to surface the current legal patent issues,  specifically in the U.S. court system; in particular, as noted in prior 'patent' postings, an observation was made that the current litigation underway will not have a wide impact (BRCA 1/2) as many other patients exist which is reflected as the one described here:

abstract

"...The simpler versions, especially BRCAPROLYTE-Plus and BRCAPROLYTE-Simple, lead to only modest loss in overall discrimination compared to BRCAPRO in this dataset. Thus, we conclude that simplified implementations of BRCAPRO can be used for genetic risk prediction in settings where collection of complete pedigree information is impractical."

also:  2012 JSM (Joint Statistical Meetings) conference abstract:
A Two-Stage Approach to Genetic Risk Prediction in Primary Care