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Abstract
Highlights
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- Statins are associated with cancer risk reduction in endometrial cancer and also in ovarian cancer (unadjusted only, due to small sample size).
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- Use of statins was associated with improved survival from endometrial and ovarian cancer
Purpose
The
use of statins has been associated with reduced risk of malignancies in
a variety of organ sites. This study was aimed at studying the effects
of statins on gynecological cancers.
Methods
The
Cancer In The Ovary and Uterus Study (CITOUS) is a case-control study
of newly diagnosed cases of gynecological malignancies and
age/sex/clinic/ethnic-group matched population controls. Use of statins
prior to and following diagnosis was assessed in a subset of 424 cases
of ovarian and endometrial cancers and 341 controls, enrolled in Clalit
Health Services (CHS), using pharmacy records.
Results
The
use of statins for more than one year prior to diagnosis was associated
with a significantly reduced risk of ovarian cancer (OR=0.56,95%
CI:0.33-0.94) and of endometrial cancer (OR=0.59,95% CI:0.40-0.87). The
association with endometrial cancer, but not with ovarian cancer
(OR=0.54, 0.26-1.13), remained statistically significant after
adjustment for fruit and vegetable consumption, sports activity, family
history of endometrial and colorectal cancer, ethnicity, BMI, duration
of breast feeding, age at 1st pregnancy and use of menopausal hormones
(RR=0.48, 0.26-0.89). Women who used statins only after diagnosis of
cancer had a significantly better survival of both ovarian cancer (Log
rank test, p=0.021, age adjusted HR=0.47, 0.26-0.85) and endometrial
cancer (p=0.06, age adjusted HR=0.45, 0.23-0.87).
Conclusion
The
use of statins for more than one year before diagnosis was associated
with a reduction in the risk of endometrial cancer and possibly ovarian
cancer. A significantly improved survival of cases of both malignancies
was noticed when statins were taken only after diagnosis.
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