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open access
Introduction
Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphism, FokI, is reported
to increase the risk of many cancers. Role of vitamin D and its receptor polymorphisms
in ovarian cancer has not been clearly defined.
Objective
To study the levels of serum vitamin D and occurrence of vitamin D receptor gene polymorphism
(FokI) in cases of ovarian cancer.
Material and methods
FokI genotyping was done by PCR-RFLP technique and vitamin D levels were estimated
by chemiluminescence immunoassay.
Results
Serum vitamin D levels were significantly (p < 0.03) lower in ovarian cancer cases
as compared to controls. The homozygous (TT) and heterozygous (CT) genotype predispose
to the development of ovarian cancer in Indian population (OR: 2.37, 95% CI: 1.04-5.44)
as compared to the homozygous (CC) genotype. Vitamin D deficiency and VDR gene polymorphism
(FokI) act non-synergistically (p value < 0.4).
Conclusion
Low blood levels of vitamin D and VDR receptor polymorphism (FokI) might be a risk
factor for the development of ovarian cancer. Other novel ligands of vitamin D receptor
might be responsible for the non-synergistic effect.
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