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June 2013
This
article will briefly summarize what we know about ‘chemo brain‘ to
date. We will discuss how PET/CT can be useful in understanding the
neurobiology of this phenomenon and, in addition, how it may be relevant
to the care of individual patients with cancer.
| Chemo brain |
|  |
The
National Cancer Institute estimates that there were 13.7 million
Americans with a history of cancer still alive in January of 2012
[101]. Over 1.6 million new cases of cancer are anticipated this year in the USA alone
[101].
Common treatments for cancer include surgery, radiotherapy and
chemotherapy. It is estimated that 25% of cancer patients receive
chemotherapy
[102].
Due to substantial progress made in the treatment of cancer, more
individuals are currently living with a history of cancer than dying
from cancer.
We are now paying the price for the success we have in
curing many cancers by having a large number of cancer survivors living
with some of the short-term and long-term side effects of chemotherapy.
One such area of interest is the phenomenon of chemo brain or, more
specifically, the aggregate of cognitive changes reported by cancer
patients after receiving chemotherapy.
Rates of cognitive changes following chemotherapy range from 15 to 75% [1,101].........
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