Exploring the biology of ‘chemo brain‘: how has PET/CT helped us?, Imaging in Medicine Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Sunday, June 16, 2013

Exploring the biology of ‘chemo brain‘: how has PET/CT helped us?, Imaging in Medicine



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June 2013

This article will briefly summarize what we know about ‘chemo brain‘ to date. We will discuss how PET/CT can be useful in understanding the neurobiology of this phenomenon and, in addition, how it may be relevant to the care of individual patients with cancer.


Chemo brain

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The National Cancer Institute estimates that there were 13.7 million Americans with a history of cancer still alive in January of 2012 [101]. Over 1.6 million new cases of cancer are anticipated this year in the USA alone [101]. Common treatments for cancer include surgery, radiotherapy and chemotherapy. It is estimated that 25% of cancer patients receive chemotherapy [102]. Due to substantial progress made in the treatment of cancer, more individuals are currently living with a history of cancer than dying from cancer. We are now paying the price for the success we have in curing many cancers by having a large number of cancer survivors living with some of the short-term and long-term side effects of chemotherapy. One such area of interest is the phenomenon of chemo brain or, more specifically, the aggregate of cognitive changes reported by cancer patients after receiving chemotherapy.
Rates of cognitive changes following chemotherapy range from 15 to 75% [1,101].........

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