Fertility Preservation and Breast Cancer (includes references to BRCA/Lynch Syndrome)

A Complex Problem

"......The two most challenging groups of patients with whom to discuss fertility preservation are probably the patients whose tumors are ER-positive, as the induction of amenorrhea has been associated with better breast cancer–related outcomes, and patients with a genetic predisposition to ovarian cancer, such as women with mutations in BRCA1/BRCA2 or with Lynch syndrome (hereditary nonpolyposis colorectal cancer [HNPCC]) genes. In women with BRCA mutations, removal of the ovaries has been strongly associated with better breast cancer outcomes and prevention of ovarian cancer...........