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Abstract
Background:
Studies
of anthropometric measures and ovarian cancer risk have predominantly
included women of European descent with mixed findings.
Methods:
Data
from the prospective Shanghai Women’s Health Study (SWHS) were used to
evaluate associations between anthropometric measures and risk of
epithelial ovarian cancer (EOC). Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated by Cox proportional hazards regression.
Results:
A total of 152 EOC cases occurred among 70 258
women. Increasing quartiles of weight, hip circumference, and weight
gain during adulthood were associated with significantly increased EOC
risks. Body mass index (BMI) was also associated; overweight (25BMI<29.99) and obese women (BMI30.0) had significantly increased risks (HR: 1.49, 95% CI: 1.05, 2.13, and HR: 2.42, 95%
CI: 1.37, 4.28, respectively). No significant associations were
observed for height, waist circumference, waist-to-hip ratio (WHR), and
waist-to-height ratio (WHER).
Conclusion:
Results
from this large prospective study of Chinese women support the
hypothesis that general adiposity contributes to the aetiology of
ovarian cancer.
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