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Abstract
Objective Defining the reliability of cancer antigen-125-related kinetics criteria versus Gynecologic Cancer Inter Group criteria in
predicting the tumor outcome after chemotherapy in patients with recurrent ovarian cancer.
Methods A
retrospective monoinstitutional assessment of CA125-related versus
Gynecologic Cancer Inter Group-related parameters was
performed after cytotoxic chemotherapy in
patients with metastatic ovarian cancer treated from 2006 to 2011. A
correlation
analysis between the response and progression
measurements has been performed, and the outcome has been reported.
Results Among 42
eligible patients, tumor response and progression calculated by CA125
kinetics, with tumor response at 8 weeks and
specific growth rate at progression, exhibited a
significant correlation with progression-free and overall survival,
similar
to tumor response and progression by Gynecologic
Cancer Inter Group criteria.
Conclusions The tumor
response at 8 weeks higher than 1.77 appears to be a good surrogate of
clinical response, whereas the definition
of progression when CA125 increases above a
value double than the nadir suggests a similar performance of growth
rate at progression
versus Gynecologic Cancer Inter Group criteria
and warrants further investigation.
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