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Abstract
Highlights
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- Aim: the incidence of synchronous endometrial/ovarian cancer in young women.
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- Unlike previous reports (11-9%), the incidence was quietly low (4.5%).
Abstract
Objective
Some
authors have recommended the use of diagnostic laparoscopy as a
pretreatment assessment step for conservative hormonal treatment in
young women with endometrial cancer. The aim of this study was to
determine the incidence of synchronous primary cancer of the endometrium
and ovary in young women.
Methods
The
medical records of 3240 patients with endometrial cancer who underwent
primary surgery between 1995 and 2010 were collected from 7 institutions
and were retrospectively reviewed. Low-risk endometrial cancer was
defined as tumors without myometrial invasion; normal or benign-looking
ovaries; normal CA-125; grade 1 endometrioid histology; and early stage
endometrial cancer on pretreatment assessment.
Results
Fifteen
percent (471/3240) were younger than 40 years of age. The incidence of
synchronous ovarian cancer in young women with endometrial cancer was
4.5% (21/471). In patients with low-risk endometrial cancer, synchronous
cancers were not identified.
Conclusion
The
incidence of synchronous ovarian malignancies in young women with
endometrial cancer was quiet low (4.5%), unlike previous studies have
revealed (11-29%). Therefore, diagnostic laparoscopy is not mandatory in
patients with low-risk early stage endometrial cancer selected for
conservative treatment to confirm the absence of ovarian malignancy.
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