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abstract
Intraperitoneal chemotherapy, involving the administration
of certain chemotherapeutic agents directly to the intraperitoneal
cavity, was developed as a novel therapeutic
strategy early in the 1950s. Intraperitoneal administration of
chemotherapy results
in higher intraperitoneal concentration of the
cytotoxic medications and minimal systemic exposure than observed with
intravenous
administration, which in turn may increase the
efficacy of these agents with substantial reduction in systemic
toxicity. Intraperitoneal
chemotherapy was used successfully in peritoneal
surface malignancies, including malignant peritoneal mesothelioma,
pseudomyxoma
peritonei, malignant ascites, sarcomatosis, and
peritoneal carcinomatosis from gastrointestinal and ovarian cancers.
Pharmacists
may play a major role in optimizing intraperitoneal
chemotherapy through verification of chemotherapy order for proper
doses,
dilution, preparation, and administration.
Moreover, pharmacists are medication experts who can provide other
health care
professionals with the necessary drug information.
Despite the local application of
chemotherapy, intraperitoneal chemotherapy is not free of systemic side
effects and can be
associated with serious complications. The benefits
of intraperitoneal chemotherapy should be weighed against its potential
harm to maximize efficacy and to minimize morbidity
and mortality as much as possible. The aim of this article is to review
the current available literature regarding the
safety and efficacy of intraperitoneal chemotherapy in cancer treatment.
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